Treating acute or chronic pain, which may have an array of causes and perpetuating factors, requires a multidisciplinary approach and customized treatment protocol to meet the specific needs of each patient.
Optimal treatment may involve the use of medications that possess pain-relieving properties, including some antidepressants, anticonvulsants, antiarrhythmics, anesthetics, antiviral agents, and NMDA (N-methyl-D-aspartate) antagonists. NMDA-receptor antagonists, such as dextromethorphan and ketamine, can block pain transmission in spinal neurons, reduce nociception, and decrease tolerance to and for the need for opioid analgesics. [Anesth Analg 2001 Mar;92(3):739-44] By combining various agents which utilize different mechanisms to alter the sensation of pain, physicians have found that smaller concentrations of each medication can be used. Genesis Pharmacy blends combinations of pain medications with anti-inflammatory AND neuropathic agents for the effective treatment of pain.
Topical and transdermal creams and gels can be formulated to provide high local concentrations at the site of application (e.g., NSAIDs for joint pain), for trigger point application (e.g., combinations of medications for neuropathic pain), or in a base that will allow systemic absorption. Studies suggest that there are no great restrictions on the type of drug that can be incorporated into a properly compounded transdermal gel.
Genesis Pharmacy collaborates with practitioners and patients to create medications in dosage forms, strengths and combinations most therapeutic for painful symptoms. Please contact our compounding pharmacist to discuss medication that will provide the greatest benefit for your patient.